S-au calificat în optimile Champions League: Manchester United, FC Basel, Paris Saint-Germain, Bayern Munchen, AS Roma, Chelsea, FC Barcelona, Juventus Torino, Liverpool, Sevilla, Manchester City, Șahtior Doneţk, Beşiktaş Istanbul, FC Porto, Tottenham Hotspur şi Real Madrid.
În şaisprezecimile de finală ale Europa League s-au calificat: ȚSKA Moscova, Celtic Glasgow, Atlético Madrid, Sporting Lisabona, Spartak Moscova, Napoli, RB Leipzig, Borussia Dortmund.
Grupa E:
Liverpool — Spartak Moscova 7-0
Au marcat: Philippe Coutinho 4 — penalty, 15, 50, Roberto Firmino 19, Sadio Mane 47, 76, Mohamed Salah 86.
NK Maribor — Sevilla 1-1
Au marcat: Tavares 10 / Paulo Ganso 75.
Grupa F:
Feyenoord Rotterdam — SSC Napoli 2-1
Au marcat: Nicolai Joergensen 33, Jerry St. Juste 90 / Piotr Zielinski 2.
Șahtior Doneţk — Manchester City 2-1
Au marcat: Bernard 26, Ismaily 32 / Sergio Aguero 90+2 — penalty.
Grupa G:
FC Porto — AS Monaco 5-2
Au marcat: Vincent Aboubakar 9, 33, Yacine Brahimi 45, Alex Telles 65, Tiquinho 82 / Kamil Glik 67 — penalty, Radamel Falcao 78.
Cartonaşe roşii: Felipe 38, respectiv Rachid Ghezzal 38.
RB Leipzig — Beşiktaş Istanbul 1-2
Au marcat: Naby Keita 87, respectiv Alvaro Negredo 10 — penalty, Anderson Talisca 90.
Grupa H:
Real Madrid — Borussia Dortmund 3-2
Au marcat: Borja Mayoral 8, Cristiano Ronaldo 12, Lucas Vazquez 81 / Pierre-Emerick Aubameyang 43, 49.
Tottenham Hotspur — APOEL Nicosia 3-0
Au marcat: Fernando Llorente 20, Heung-Min Son 37, Georges N’Koudou 80.
