- Lokomotiv Moscova – Fenerbahce 1-1 (Samedov 45 / Topal 83)
- Bilbao – Marseille 1-1 (Merino 81 / Batshuayi 41)
- Krasnodar – Sparta Praga 0-3 (Marecek 51, Frydek 57, Fatai 70)
- Lazio – Galatasaray 3-1 (Parolo 59, Anderson 60, Klose 73 / Oztekin 62)
- Bayer Leverkusen – Sporting Lisabona 3-1 (Bellarabi 30, 65, Calhanoglu 87/ Mario 38)
- Liverpool – Augsburg 1-0 (Milner pen. 5)
- Rapid Viena – Valencia 0-3 (Rodrigo 59, Feghouli 64, Piatti 72)
- Schalke 04 – Şahtior 0-4 (Marlos 27, Ferreyra 63, Kovalneko 77, Mustafi 88 – aut.)
- FC Basel – Saint Etienne 2-1 (Zuffi 15, 90+2 / Sall 90)
- FC Porto – Borussia Dortmund 0-1 (Aubameyang 23)
- Manchester United – Midtylland 5-1 (Bodurov autogol 32, Rashford 63, 75, Herrera 87- pen, Depay 90 / Sisto 28)
- Molde – Sevilla 1-0 (Hestad 43)
- Napoli – Villarreal 1-1 (Hamsik 17 / Pina 59) *Chiricheş a fost titular
- Olympiakos – Anderlecht 1-2 (Fortounis pen. 29 / Acheampong 103, 112)
- Tottenham – Fiorentina 3-0 (Mason 25, Lamela 63, Rodriguez autogol 81)
Echipele calificate: Fenerbahce, Sparta Praga, Lazio, Leverkusen, Liverpool, Valencia, Şahtior, Bilbao, FC Basel, Dortmund, Manchester Unted, Sevilla, Tottenham şi Braga.
